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(Investigative Ophthalmology and Visual Science. 1974;13:617-619.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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The Dual Nature of Pilocarpine to Stimulate or Inhibit the Formation of Aqueous Humor

FRANK J. MACRI 1 and STANLEY J. CEVARIO 2

1 Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare, Bethesda, Md. 20014
2 Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare, Bethesda, Md. 20014.

In the enucleated, arterially perfused cat eye, pilocarpine has been found capable of both increasing and decreasing the rate of aqueous humor formation. Utilizing pharmacologic criteria, the increased formation rate is ascribed to a stimulatory action on E2 sites of sympathetic ganglion-like receptors. The inhibitory response of pilocarpine is attributed to a stimulatory action on E2 sites of similar ganglion-like receptors.

Submitted on April 8, 1974






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