IOVS Circulation
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(Investigative Ophthalmology and Visual Science. 1974;13:688-691.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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The Effects of Theophylline on Cyclic Adenosine Monophosphate Metabolism in Lymphocytes from Open-Angle Glaucoma Patients

HERBERT L. CANTRILL 1, HARRY A. ZINK 1, STEPHEN R. WALTMAN 1, and BERNARD BECKER 1

1 Department of Ophthalmology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Mo. 63110

The effects of theophylline on cyclic-AMP metabolism were evaluated in lymphocytes from individuals tested topically with corticosteroids and from patients with open-angle glaucoma. Lymphocyte cyclic-AMP phosphodiesterase activity, and kinetic constants were similar in all groups. Theophylline inhibited the enzyme in all groups at similar concentrations and caused an equal rise in cyclic-AMP levels in lymphocytes from each group. It is concluded that the differential effects of theophylline on inhibition of phytohemagglutinin-stimulated lymphocyte transformation in the tested groups cannot be explained by its effect on cyclic-AMP metabolism.

Key Words: glaucoma • theophylline • phosphodiesterase • lymphocyte transformation • cyclic adenosine monophosphate (cAMP)

Submitted on May 14, 1974






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