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(Investigative Ophthalmology and Visual Science. 1974;13:700-701.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Light-Dependent Ca++ Content of Rod Outer Segment Disc Membranes

P. A. LIEBMAN 1

1 Department of Anatomy, University of Pennsylvania, Philadelphia, Pa.

Retinal rod outer segment disc membranes are found to bind Ca++. The Ca++ bound increases with that in the medium and after light exposure. The use of EGTA in the medium to prevent re-entry of released Ca++ unmasks a light-induced Ca++ loss from the disc membranes. Released Ca++ may be accompanied by phosphate. Our results are consistent with the Ca++ coupling hypothesis of visual transduction.

Key Words: transduction • calcium • membrane • discs • rods

Submitted on May 13, 1974




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