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Investigative Ophthalmology & Visual Science, Vol 14, 40-42, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Adenosine 3',5'-monophosphate increases the outflow of aqueous humor from the rabbit eye

AH Neufeld, DK Dueker, T Vegge and ML Sears

Direct administration of cyclic-AMP into the anterior chamber increases the outflow facility of the eye for aqueous humor. This is consistent with the hypothesis that catecholamines lower the intraocular pressure of the rabbit eye, at least in part, by a cyclic-AMP-mediated mechanism. This mechanism is active in the outflow channels and increases the rate at which aqueous humor leaves the anterior chamber.


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