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Investigative Ophthalmology & Visual Science, Vol 14, 785-787, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Binding of retinol to isolated retinal pigment epithelium in the presence and absence of retinol-binding protein

G Maraini and F Gozzoli

Isolated human and bovine pigment epithelium actively binds H3-retinol when vitamin A alcohol is present in the incubation medium bound to human retinol-binding protein. Pigment epithelium is unable to bind retinol present in the incubation solution as the free form, i.e., not bound to its physiologic carrier protein. It is suggested that an interaction between retinol-binding protein and the membranes of pigment epithelial cells is essential for the active transport of retinol into pigment epithelium.


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R. Kawaguchi, J. Yu, P. Wiita, J. Honda, and H. Sun
An Essential Ligand-binding Domain in the Membrane Receptor for Retinol-binding Protein Revealed by Large-scale Mutagenesis and a Human Polymorphism
J. Biol. Chem., May 30, 2008; 283(22): 15160 - 15168.
[Abstract] [Full Text] [PDF]


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Copyright © 1975 by the Association for Research in Vision and Ophthalmology