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Investigative Ophthalmology & Visual Science, Vol 14, 840-847, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The electroretinogram in dogs with inherited cone degeneration

GD Aguirre and LF Rubin

The electroretinogram (ERG) of hemeralopic Alaskan malamute dogs contains only rod components. There is absence of the photopic b-wave which is normally elicited with red light stimuli during dark adaptation and, using flicker stimulation, only the first or rod branch of the flicker fusion response curve is present. At high stimulus intensity levels, the flicker response of hemeralopes is absent. A normal ERG is recorded from affected dogs using blue light stimuli and low intensity white light. In the adult hemeralope, the retina contains no cones.


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 Hum Mol GenetHome page
D. J. Sidjanin, J. K. Lowe, J. L. McElwee, B. S. Milne, T. M. Phippen, D. R. Sargan, G. D. Aguirre, G. M. Acland, and E. A. Ostrander
Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
Hum. Mol. Genet., August 1, 2002; 11(16): 1823 - 1833.
[Abstract] [Full Text] [PDF]


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