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Investigative Ophthalmology & Visual Science, Vol 14, 232-235, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Drugs affecting the cholinergic system in the intact mammalian eye. I. Evaluation of the miotic activity of acetylcholine-like drugs in the mouse eye

S Maayani, G Treister and M Sokolovsky

The effect of concentration and pH on the miotic activity of five acetylcholine-like drugs were studied in the intact mouse eye. The data suggests that it is mainly the nonionized form of the drug which contributes to its miotic activity. Acetylcholine-like drugs, degradable by cholinesterases, exert their miotic activity at higher concentrations than do those which are resistant to enzymatic hydrolysis. More active acetylcholine-like drugs appear to be less sensitive to concentration changes.




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Copyright © 1975 by the Association for Research in Vision and Ophthalmology