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Investigative Ophthalmology & Visual Science, Vol 14, 688-689, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye

AH Neufeld and ML Sears

Our previous studies showed that cyclic-AMP increases the outflow facility of the eye of the rabbit. In this investigation, an analogue of cyclic-AMP, the 8-methylthio derivative, perfused into the anterior chamber of the eye of the vervet monkey, increased outflow facility twofold. This observation supports the hypothesis that cyclic-AMP mediates the action of adrenergic agents to reduce intraocular pressure in the primate eye.


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Copyright © 1975 by the Association for Research in Vision and Ophthalmology