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(Investigative Ophthalmology and Visual Science. 1963;2:58-62.)
© 1963 by The Association for Research in Vision and Ophthalmology, Inc.

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Effect of X-Irradiation on the Development of Immunogenic Uveitis

ARTHUR M. SILVERSTEIN 1

1 Immunobiology Branch, Armed Forces Institute of Pathology, Washington, D. C.

Rabbits receiving an intravitreal injection of egg albumin develop a spontaneous immunogenic uveitis about 7 days later. If, 24 hours prior to antigen injection, the rabbits are given 450 r of x-irradiation to the body with the eyes shielded, the ocular inflammatory response is suppressed. X-irradiation of the eyes alone with the rest of the body shielded does not inhibit the development of uveitis. These data indicate that in this primary response to antigen, active sensitization of ocular tissues does not occur to any appreciable extent, and. that the inflammatory cells which infiltrate the uveal tract originate extraocularly.






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Copyright © 1963 by the Association for Research in Vision and Ophthalmology