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Investigative Ophthalmology & Visual Science, Vol 22, 165-173, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Pathologic mechanisms of multifocal choroiditis with retinal detachment after carotid injection of Streptococcus mutans and other bacteria in dogs

SM Meyers, ML Vasil and L Yamamoto

Multifocal choroiditis with overlying retinal detachment occurs after carotid injection of certain bacteria in dogs. The ocular lesions occur mainly in the tapetal area of the retina, correlate with microabscesses in the inner choroid and subretinal space, and occasionally occur in the inner retina and anterior uveal tract. The major pathophysiologic factor involved in the dog model of septic choroiditis appears to be embolization of the choriocapillairies by "live" bacteria, which clump and adhere well to tissues. In the dosages used, antibiotics did not prevent or alter the severity of the fundus lesions.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology