IOVS Hypertension
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Datiles, M.
Right arrow Articles by Kinoshita, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Datiles, M.
Right arrow Articles by Kinoshita, J. H.

Investigative Ophthalmology & Visual Science, Vol 22, 174-179, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study

M Datiles, H Fukui, T Kuwabara and JH Kinoshita

Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using plastic embedding with methacrylate. Untreated rats developed nuclear cataracts by 14 days and mature cataracts by 21 days. However, rats treated with the aldose reductase inhibitor sorbinil did not develop any cataractous change for up to 8 months of 50% galactose feeding and could not be distinguished from normal controls. This strongly suggests that aldose reductase is the common factor involved in the formation of sugar cataracts.


This article has been cited by other articles:


Home page
 IOVSHome page
N. Oishi, S. Morikubo, Y. Takamura, E. Kubo, S. Tsuzuki, T. Tanimoto, and Y. Akagi
Correlation between Adult Diabetic Cataracts and Red Blood Cell Aldose Reductase Levels
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 2061 - 2064.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
W. Robison Jr, P. Kador, and J. Kinoshita
Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor
Science, September 16, 1983; 221(4616): 1177 - 1179.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Association for Research in Vision and Ophthalmology