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Investigative Ophthalmology & Visual Science, Vol 22, 186-190, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Phase separation of X-irradiated lenses of rabbit

JI Clark, FJ Giblin, VN Reddy and GB Benedek

The phase separation temperature (Tcat) was studied as a function of time (age) after the administration of a single dose of radiation (2000 rad), which induces cataract in the rabbit lens. In the normal unirradiated lens, Tcat decreases linearly with age at a rate (DTcat/dt) approximately 2.2 degrees/week. In the irradiated lens, Tcat initially decreases with age much less than the normal lens, then rises sharply with age at the time of the appearance of opacity in the living rabbit eye. We suggest that the phase separation temperature may serve as a sensitive and early indicator of cataractogenic processes in the lens.


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