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Investigative Ophthalmology & Visual Science, Vol 22, 213-219, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

HLA-B27, Klebsiella pneumoniae, and the relation to acute anterior uveitis

EJ Holland, AB Loren, MJ O'Donnell, DJ Spence, HH Tessler and MM Yokoyama

Acute anterior uveitis (AAU) is a disease of unknown etiology, although it is frequently associated with various autoimmune diseases. It has recently been shown in patients with ankylosing spondylitis (AS), a disease often associated with AAU, that antiserum raised against a particular isolate of Klebsiella pneumoniae would cross-react with lymphocytes possessing HLA-B27. The present study was performed to evaluate the response of lymphocytes of patients to K. pneumoniae and to determine the correlation with HLA-B27. The circulating immune complex levels in the serum of the patients were also determined for correlation with the presence of HLA-B27 antigen. We were able to demonstrate this cross-reactivity in the samples of AAU patients; however, we did find an increased immune complex level that was independent of HLA-B27 antigen. From our results, we conclude that although AAU is clinically associated with AS, the role of K. pneumoniae in these disease states remains unclear.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology