IOVS Journal of Clinical Investigation
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Investigative Ophthalmology & Visual Science, Vol 22, 376-381, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Human corneal stroma contains three distinct collagens

DA Newsome, J Gross and JR Hassell

Acetic acid-pepsin extracts of normal human corneal stromas were shown by carboxymethyl cellulose-column chromatography, sodium dodecyl sulfate-slab gel electrophoresis, highly purified collagenase, trypsin sensitivity, and cyanogen bromide peptide mapping to contain types I, III, and IV collagen, with type I by far the predominant species. This degree of collagen heterogeneity in normal human corneal stroma has not been reported previously and may be important in the understanding of wound healing and disease states.


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