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Investigative Ophthalmology & Visual Science, Vol 22, 599-605, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Glucocorticoid receptor binding in bovine lens

EJ Wenk, MR Hernandez, BI Weinstein, GG Gordon, MW Dunn and AL Southren

The present study demonstrates glucocorticoid receptor localization in the nuclei of cells of the anterior epithelium and bow region and its absence in all other regions of the lens. Both autoradiographic and biochemical studies show that triamcinolone acetonide is inactive whereas tetrahydrocortisol (previously considered to be an inactive metabolite of cortisol) is an active competitor of dexamethasone binding to the glucocorticoid receptor in the bovine lens. The consistency of these findings by both techniques supports the validity of this observation. In addition, it indicates that autoradiography can be used for studying glucocorticoid agonist/antagonist relationships in the human lens, where only small amounts of tissue are available.


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E. R. James, L. Robertson, E. Ehlert, P. Fitzgerald, N. Droin, and D. R. Green
Presence of a Transcriptionally Active Glucocorticoid Receptor {alpha} in Lens Epithelial Cells
Invest. Ophthalmol. Vis. Sci., December 1, 2003; 44(12): 5269 - 5276.
[Abstract] [Full Text] [PDF]


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Copyright © 1982 by the Association for Research in Vision and Ophthalmology