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Investigative Ophthalmology & Visual Science, Vol 22, 643-650, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effects of cytochalasins and colchicine on the ultrastructure of migrating corneal epithelium

IK Gipson and L Keezer

To determine the effects of cytochalasins and colchicine on the ultrastructure of migrating corneal epithelium of the rat, abraded corneas healing in organ culture were cultured for 30 min in the presence of these cytoskeletal-perturbing drugs. Transmission and scanning electron microscopy of these corneas indicate the following. (1) Cytochalasins B (1 microgram/ml of medium) and D (0.1 microgram/ml of medium) caused drastic alteration in structure of cells of the leading edge only. Stratified layers of cells behind the leading edge were unaffected. This observation may indicate that it is the cells of the leading edge which have a rapid turnover of actin filament formation during epithelial sheet movement. (2) Both cytochalasins caused surface blebs or zeiotic processes to form on cells of the leading edge. The shape of the processes caused by the cytochalasins differed, however. Actin filaments accumulated in the cytoplasm under the zeiotic processes. (3) Colchicine had no effect on the ultrastructure of migrating epithelium.


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Y Danjo and I. Gipson
Actin 'purse string' filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement
J. Cell Sci., January 11, 1998; 111(22): 3323 - 3332.
[Abstract] [PDF]


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Copyright © 1982 by the Association for Research in Vision and Ophthalmology