Investigative Ophthalmology & Visual Science, Vol 22, 695-700, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The sensitivity of rat rod outer segment disc shedding to light

AI Goldman

Albino rats were raised in cyclic lighting and subjected to either constant light inhibition of the shedding peak or a 10 hr phase advance in the lighting schedule, with lighting levels of varied intensity. All responses followed sigmoid curves of shedding vs. intensity. For constant light inhibition the curve had a shallow slope with a 50% peak at 0.85 ft-cd. Shedding after a phase shift showed a steep curve with a 50% peak at 0.3 ft-cd when animals were observed at 9:30 P. M. and a shallow slope with a 50% peak at 0.003 ft-cd when observed at 7:30 A. M. It is concluded that the mechanisms of shedding inhibition and phase shifts in the shedding rhythm differ with respect to the role of light.

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