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Investigative Ophthalmology & Visual Science, Vol 22, 788-795, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Herpetic keratitis in zinc-deficient rabbits

LS Feiler, G Smolin, M Okumoto and D Condon

In a study of 57 rabbits, we found that zinc played a vital role in the growth of the rabbit and in its immunocompetence. Both humoral and cellular immunity were depressed in the zinc-deficient rabbit. Not only did zinc-deficient animals fail to gain weight, differing in that respect from rabbits on a regular diet, but they also had a high death rate, in contrast with no deaths among normal rabbits. Herpes simplex virus keratitis, both epithelial and stromal, was more severe in the zinc-deficient rabbit but was not improved by local zinc replacement (zinc sulphate ointment, 0.05%); Zinc sulphate ointment (1%), which is four times stronger than commercially available zinc ophthalmic preparations, was severely toxic for the rabbit cornea.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology