Investigative Ophthalmology & Visual Science, Vol 23, 73-80, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Limbal epithelium in ocular surface wound healing

S Kinoshita, TC Kiorpes, J Friend and RA Thoft

The regenerated epithelium derived from limbal epithelium was histologically and biochemically compared with epithelia regenerated from corneal and bulbar conjunctival epithelia. The histologic results indicated that regenerated epithelium of limbal origin increased in thickness with time after healing and showed no goblet cell appearance on the cornea. This suggests that regenerated epithelium from the limbus is more like regenerated epithelium of corneal origin than that of bulbar conjunctival origin. However, the glycogen content and protein pattern profile showed that regenerated epithelium of limbal origin had characteristics intermediate between those of corneal and bulbar conjunctival origin. Thus it is proposed that there are three distinct types of ocular surface epithelia--corneal, bulbar conjunctival, and limbal--and that limbal epithelium behaves differently from corneal and conjunctival epithelia in ocular surface wound healing.

This article has been cited by other articles:

				T.-T. Sun Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing Am J Physiol Renal Physiol, July 1, 2006; 291(1): F9 - F21. [Abstract] [Full Text] [PDF]

				K.-S. Park, C. H. Lim, B.-M. Min, J. L. Lee, H.-Y. Chung, C.-K. Joo, C.-W. Park, and Y. Son The side population cells in the rabbit limbus sensitively increased in response to the central cornea wounding. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 892 - 900. [Abstract] [Full Text] [PDF]

				J. He, N. G. Bazan, and H. E. P. Bazan Alkali-Induced Corneal Stromal Melting Prevention by a Novel Platelet-Activating Factor Receptor Antagonist Arch Ophthalmol, January 1, 2006; 124(1): 70 - 78. [Abstract] [Full Text] [PDF]

				P. Arpitha, N. V. Prajna, M. Srinivasan, and V. Muthukkaruppan High Expression of p63 Combined with a Large N/C Ratio Defines a Subset of Human Limbal Epithelial Cells: Implications on Epithelial Stem Cells Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3631 - 3636. [Abstract] [Full Text] [PDF]

				H. S DUA, A. J KING, and A. JOSEPH A new classification of ocular surface burns Br. J. Ophthalmol., November 1, 2001; 85(11): 1379 - 1383. [Full Text] [PDF]

				T. R M Henderson, D. J Coster, and K. A Williams The long term outcome of limbal allografts: the search for surviving cells Br. J. Ophthalmol., May 1, 2001; 85(5): 604 - 609. [Abstract] [Full Text]

				H. S Dua and A. Azuara-Blanco Autologous limbal transplantation in patients with unilateral corneal stem cell deficiency Br. J. Ophthalmol., March 1, 2000; 84(3): 273 - 278. [Abstract] [Full Text]

				N. Di Girolamo, N. Tedla, R. K Kumar, P. McCluskey, A. Lloyd, M. T Coroneo, and D. Wakefield Culture and characterisation of epithelial cells from human pterygia Br. J. Ophthalmol., September 1, 1999; 83(9): 1077 - 1082. [Abstract] [Full Text]

				H. S Dua and A. Azuara-Blanco Allo-limbal transplantation in patients with limbal stem cell deficiency Br. J. Ophthalmol., April 1, 1999; 83(4): 414 - 419. [Abstract] [Full Text]