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Investigative Ophthalmology & Visual Science, Vol 23, 147-153, Copyright © 1982 by Association for Research in Vision and Ophthalmology


ARTICLES AND REPORTS

Localization of substance P-like immunoreactivity within the monkey retina

N Brecha, A Hendrickson, I Floren and HJ Karten

Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the antiserum with 10 micro M synthetic SP. Specific SP-like immunoreactivity was observed within varicose processes located in the outer plexiform layer, inner nuclear layer (INL), and in three bands within the inner plexiform layer (IPL). SP-immunoreactive somata were located in the proximal INL, IPL, and ganglion cell layer. These studies have thus identified SP-containing amacrine cells, interstitial amacrine cells, and displayed amacrine cells. In addition, these studies suggest the existence of SP- containing interplexiform cells and perhaps ganglion cells.


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J. Troger, S. Neyer, C. Heufler, H. Huemer, E. Schmid, U. Griesser, M. Kralinger, B. Kremser, I. Baldissera, and G. Kieselbach
Substance P and Vasoactive Intestinal Polypeptide in the Streptozotocin-Induced Diabetic Rat Retina
Invest. Ophthalmol. Vis. Sci., April 1, 2001; 42(5): 1045 - 1050.
[Abstract] [Full Text]




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