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Investigative Ophthalmology & Visual Science, Vol 23, 214-217, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Estrogens induce lipoxygenase derivative formation in rabbit lens

M Guivernau, A Terragno, MW Dunn and NA Terragno

The effect of estrogens on arachidonic acid metabolism was studied in lenses from normal and sex hormone-treated female rabbits. Analysis of the metabolites derived from incubation of these lenses with (1-14C) arachidonic acid provides the first evidence that estradiol activates the lipoxygenase pathway, as indicated by 5-S-hydroxy-6,8,11,14- eicosatetraenoic acid--like product formation, an effect that can be prevented by progestin treatment. Prostaglandin synthesis was not demonstrated by the control or estrogen-treated rabbit lenses, suggesting that lipoxygenase is the major arachidonic acid pathway in the lens.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology