IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lerman, S.
Right arrow Articles by Gardner, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lerman, S.
Right arrow Articles by Gardner, K.

Investigative Ophthalmology & Visual Science, Vol 23, 218-226, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Nuclear magnetic resonance analyses of the cold cataract: whole lens studies

S Lerman, DL Ashley, RC Long Jr, JH Goldstein, JM Megaw and K Gardner

Pulse nuclear magnetic resonance (NMR) magnetization decay studies were performed on normal and cold cataractous rat lenses. Computer analyses of the decay curves have been interpreted to reflect two types of water within the lens that do not exchange rapidly. Upon lowering the temperature in the presence and absence of 5% acrylamide (a known agent that prevents the cold cataract phenomenon), significant differences in the relaxation rates of one water fraction were noted. 2H (NMR) spectra on young rabbit and human lenses showed temperature-related linewidth changes, which are significantly diminished in lenses incubated in acrylamide. 31P spectra also showed similar inorganic phosphate linewidth changes and also reflected progressive alterations in the metabolic state of these lenses. These studies demonstrate the potential of NMR methods for monitoring physicochemical parameters in the normal and cataractous mammalian lens.


This article has been cited by other articles:


Home page
 ScienceHome page
W. Williams and J. Odom
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy
Science, July 11, 1986; 233(4760): 223 - 225.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Association for Research in Vision and Ophthalmology