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Investigative Ophthalmology & Visual Science, Vol 23, 240-245, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effects of intravitreally injected DL-alpha-aminoadipic acid on the c- wave of the D.C.-recorded electroretinogram in albino rabbits

E Welinder, O Textorius and SE Nilsson

The D.C. electroretinogram of four adult albino rabbits was studied 13.5 to 15 hr after injection of 0.1 ml of 0.15M DL-alpha-aminoadipic acid (alpha-AAA) into the vitreous body of one eye. The other eye was similarly injected with saline and served as control. In the alpha-AAA-- treated eye the b-wave was markedly reduced or absent and the a- and c- waves increased compared with the control eye. Sincs alpha-AAA damages the Muller cells, the results support the view that these cells are related to the generation of the b-wave and to the negative slow PIII- potential, which modifies the positive pigment epithelial component of the c-wave.


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