IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, L.
Right arrow Articles by Polgar, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, L.
Right arrow Articles by Polgar, P.

Investigative Ophthalmology & Visual Science, Vol 23, 378-382, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of ascorbate, hydroperoxides, and bradykinin on prostaglandin production by corneal and lens cells

L Taylor, M Menconi, MH Leibowitz and P Polgar

Epithelial cells from the rabbit cornea, fibroblasts from the rabbit and calf cornea, and calf lens epithelial cells were placed in individual cultures. Prostaglandin (PG) synthesis by these cell types was determined. Lens epithelial cells produced no detectable PGs under basal conditions. Corneal fibroblasts primarily produced PGE2, while epithelial cells primarily produced thromboxane A2. PG production by corneal fibroblasts was highly responsive to bradykinin, ascorbic acid, hydrogen peroxide, and t-butyl hydroperoxide, an organic peroxide. Quantitative differences in PG production between the rabbit and calf corneal fibroblasts were observed. Our results suggest that the reported therapeutic actions of ascorbic acid in the eye may, at least in part, be mediated through the PGs. Our results also support the proposed role for hydroperoxides in the control of PG synthesis.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
K. Liliom, Z. Guan, J.-L. Tseng, D. M. Desiderio, G. Tigyi, and M. A. Watsky
Growth factor-like phospholipids generated after corneal injury
Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1065 - C1074.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Association for Research in Vision and Ophthalmology