IOVS Molecular Human Reproduction
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Investigative Ophthalmology & Visual Science, Vol 23, 489-500, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Heterotopic corneal grafting in mice: a new approach to the study of corneal alloimmunity

JW Streilein, J McCulley and JY Niederkorn

Heterotopic grafting of murine corneas to the thoracic cage of recipient mice affords an opportunity to study the alloimmune rejection process in this well-characterized laboratory species. Immune rejection of cornea allografts can be reliably identified by direct visual, slit- lamp, and histologic observations. Virtually intact syngeneic corneal epithelium and stroma survive at the heterotopic site for at least 21 days. Allogeneic corneal epithelium is destroyed by an intense fibrovascular infiltrative process. If Descemet's membrane is preserved, integrity of the stroma and epithelium of syngeneic corneal grafts is preserved, whereas when this membrane is broken, progressive stromal deterioration sets in. This property of Descemet's membrane is particularly apparent in allogeneic corneal grafts.


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Copyright © 1982 by the Association for Research in Vision and Ophthalmology