IOVS Journal of General Physiology
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Investigative Ophthalmology & Visual Science, Vol 23, 501-506, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effects of methylprednisolone acetate on macromolecular synthesis and glucose oxidation in epithelial cells of the ocular surface

WJ O'Brien and DH Geroski

Epithelial cells that re-epithelialized corneas after the normal corneal epithelium was removed limbus to limbus by scraping were found to be metabolically responsive to methylprednisolone acetate. Seventy- two hours after scraping, the re-epithelializing cells from steroid- treated animals were found to have a 26% slower rate of DNA synthesis, a 30% slower rate of glucose oxidation via glycolysis, and a 79% greater rate of RNA synthesis with no apparent change in gross protein synthesis as compared with vehicle-treated controls. The DNA content of the epithelial layer isolated from steroid-treated corneas was reduced by 31% as compared with that of vehicle-treated controls.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology