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Investigative Ophthalmology & Visual Science, Vol 23, 525-528, Copyright © 1982 by Association for Research in Vision and Ophthalmology


ARTICLES AND REPORTS

Increased concentration of glucocorticoid receptors in rabbit iris-- ciliary body compared to rabbit liver

GR McCarty and B Schwartz

Dexamethasone binding to both rabbit iris-ciliary body and rabbit liver glucocorticoid receptors was compared by means of a batch assay in which the binding components were adsorbed to hydroxylapatite. The results showed that homogenates of both the rabbit iris-ciliary body and the rabbit liver contained a single class of high-affinity receptors. Binding affinity was virtually identical for the two receptors. A comparison of total binding sites in homogenates of the iris-ciliary body and the liver revealed that the iris-ciliary body glucocorticoid receptor was present in nearly twice the concentration of the hepatic receptor.





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Copyright © 1982 by the Association for Research in Vision and Ophthalmology