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Investigative Ophthalmology & Visual Science, Vol 23, 715-718, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Aqueous immune complexes in immunogenic uveitis

EL Howes Jr, DH Char and M Christensen

A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology