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Investigative Ophthalmology & Visual Science, Vol 24, 1413-1417, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Altered cortisol metabolism in cells cultured from trabecular meshwork specimens obtained from patients with primary open-angle glaucoma

AL Southren, GG Gordon, PR Munnangi, J Vittek, J Schwartz, C Monder, MW Dunn and BI Weinstein

Cells cultured from trabecular meshwork specimens obtained from patients with primary open angle glaucoma (TMPOAG cells) exhibited two major differences in cortisol-metabolizing enzymes when compared with similar cells from nonglaucomatous patients. One is a marked increase (greater than 100-fold) in delta 4-reductase activity and the other is a decrease (4-fold) in 3-oxidoreductase activity. Peripheral lymphocytes from one of these patients as well as from five additional patients with POAG, did not show these abnormalities, indicating that the defects are not found in all cortisol-metabolizing cells. The abnormal metabolism of cortisol by TMPOAG cells may be of significance in the pathogenesis of POAG.


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S. Husain, I. Kaddour-Djebbar, and A. A. Abdel-Latif
Alterations in Arachidonic Acid Release and Phospholipase C-{beta}1 Expression in Glaucomatous Human Ciliary Muscle Cells
Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1127 - 1134.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology