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Investigative Ophthalmology & Visual Science, Vol 24, 1426-1429, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors

M Jacobson, YR Sharma, E Cotlier and JD Hollander

Sorbitol, resulting from glucose metabolism through aldose reductase, may play a role in diabetic complications such as cataracts, neuropathy, and vasculopathy. Sulindac (Clinoril) and sorbinil, two inhibitors of aldose reductase, decreased sorbitol formation in cataract or nerve tissue incubated in high glucose TC-199 media. Sulindac, a widely used anti-rheumatic drug, may have clinical applications in preventing diabetic complications.


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology