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Investigative Ophthalmology & Visual Science, Vol 24, 1480-1488, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effects of alpha-aminoadipate isomers on the morphology of the isolated chick embryo retina

DS Casper and L Reif-Lehrer

The glutamate analogue, alpha-aminoadipate (alpha AA), was administered in the DL-, D-, and L-forms to chick embryo retinas in vitro. Two-hour incubation of retinas, with each form of alpha AA, resulted in glial swelling of progressive severity as the concentration of the adipate increased. Damage was most severe with the L-isomer, which produced a mixed glial-neuronal lesion that affected inner neuronal structures. The effect of the D,L racemic mixture was limited to glia and was less severe than damage seen with the L-isomer. The D-isomer produced effects similar to, but less severe than, those seen with the D,L mixture. Neuronal damage was seen subsequent to extensive Muller cell swelling in longterm cultures (24 hours) with the L- and DL-isomers. In contrast, the D-isomer did not produce discernible neurotoxicity even after a 24-hour treatment with 2.4 mM. Morphologic changes resulting from 2-hour adipate treatment were, to a large extent, reversible.


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M. Takeda, A. Takamiya, J.-w. Jiao, K.-S. Cho, S. G. Trevino, T. Matsuda, and D. F. Chen
{alpha}-Aminoadipate Induces Progenitor Cell Properties of Muller Glia in Adult Mice
Invest. Ophthalmol. Vis. Sci., March 1, 2008; 49(3): 1142 - 1150.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology