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Investigative Ophthalmology & Visual Science, Vol 24, 1519-1524, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil

RN Frank, RJ Keirn, A Kennedy and KW Frank

Normotensive and spontaneously hypertensive rats fed a 30% galactose diet until 15-21 months of age developed significant (P less than 0.05) retinal capillary basement membrane thickening, compared with animals fed a standard test diet. Animals on the high galactose diet containing 250 mg/kg of the aldose reductase inhibitor, Sorbinil, did not develop basement membrane thickening. No cytologic abnormalities of pericytes or endothelial cells were noted, and pericyte:endothelial cell nuclear ratios did not differ in the various experimental groups. This model reproduces a characteristic lesion of diabetes mellitus in non-diabetic animals, and should facilitate study of the biochemical mechanisms of basement membrane thickening.


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