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Investigative Ophthalmology & Visual Science, Vol 24, 1626-1629, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of K-582, a new antifungal agent, on experimental Candida keratitis

S Ohno, DJ Fuerst, M Okumoto, G Grabner and G Smolin

K-582, a new basic peptide antibiotic, was tested in rabbits with experimental Candida keratitis. It was shown that the K-582-treated group showed statistically highly significant therapeutic effects on days 2 and 3, as compared with the control group (day 2: P less than 0.001; day 3: P less than 0.001). The culture study showed that the average number of colonies was 1,573.1 in the controls and 463.3 in the treated group, and the difference was highly significant statistically (P less than 0.001). No ocular or systemic toxic effects were observed with this drug. K-582 is a promising new drug for the treatment of Candida keratitis.




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Copyright © 1983 by the Association for Research in Vision and Ophthalmology