Investigative Ophthalmology & Visual Science, Vol 24, 442-450, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The photopic electroretinogram in congenital stationary night blindness with myopia

P Lachapelle, JM Little and RC Polomeno

Previous studies have reported that subjects affected with congenital stationary night blindness and myopia demonstrated some photopic (cone) abnormalities in their electroretinogram (ERG). By comparing the photopic ERG elicited with a threshold and a suprathreshold stimulus it was found that, at threshold, no significant differences were noted both in the peak time and in the amplitude of ERGs evoked from CSNB and normal subjects. However, a more powerful stimulus (16 times the threshold) yields a significant difference in the ERGs recorded from the two groups. ERGs recorded from CSNB patients are decreased in amplitude with a b-wave peak time that remains normal. First derivative analysis of the ERG wave along with a selective recording of the oscillatory components of the ERG suggest that the only visible anomaly in the suprathreshold photopic ERG of CSNB patients is an absence of the two oscillations normally seen on the ascending portion of the b- wave. Data obtained on normal subjects are also reported that try to explain the functional significance of these two oscillatory potentials.

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