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Investigative Ophthalmology & Visual Science, Vol 24, 637-639, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The penetration of gentamicin into the vitreous humor in man

E Rubinstein, J Goldfarb, G Keren, M Blumenthal and G Treister

Twenty-two patients received gentamicin intramuscularly or subconjunctivally 35-220 min prior to undergoing ocular surgery. There were no detectable gentamicin levels in the vitreous humor of patients who received the drug systemically. Of the patients who received gentamicin subconjunctivally, three quarters had no detectable gentamicin levels, only three of these patients had therapeutic concentrations in their vitreous humor. These results confirm kinetic drug studies performed in animals in which low or absent vitreal gentamicin levels were observed following systemic and subconjunctival administrations. It is suggested that intravitreal injection of aminoglycosides is required in the treatment of bacterial endophthalmitis.




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Copyright © 1983 by the Association for Research in Vision and Ophthalmology