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Investigative Ophthalmology & Visual Science, Vol 24, 647-650, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

An animal model of trachoma: IV. The failure of local immunosuppression to reveal inapparent infection

HR Taylor, SL Johnson, J Schachter and RA Prendergast

Repeated inoculation with live chlamydia trachomatis is necessary to develop a model of trachoma in monkeys. However, it is not possible to reisolate chlamydia from the monkey's eye after the first 1 or 2 months of weekly reinoculation. The effect of subconjunctival steroid injections in monkeys that had received weekly inoculations with live chlamydia is reported. Despite a profound suppression of local inflammation, steroid treatment did not produce a reactivation of identifiable chlamydial infection as determined by repeated chlamydial cultures and cytologic examinations.




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Copyright © 1983 by the Association for Research in Vision and Ophthalmology