IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flach, A. J.
Right arrow Articles by Wood, I. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flach, A. J.
Right arrow Articles by Wood, I. S.

Investigative Ophthalmology & Visual Science, Vol 24, 766-771, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Ptosis in the rat following topically administered 2% epinephrine

AJ Flach, JS Peterson, MF Roizen and IS Wood

Commercially available 2% epinephrine instilled twice daily in one eye of 15 rats resulted in ptosis after 4 weeks treatment. The ptosis was indistinguishable from that observed following topical treatment with 6- hydroxydopamine 20% and surgical sympathectomy. Ptosis in both epinephrine- and 6-hydroxydopamine-treated rats was associated with a statistically significant depletion of ocular norepinephrine, as determined by a sensitive catecholamine radio enzyme assay. Ultrastructural evidence of nerve terminal degeneration was present near the smooth muscle of Muller within the eyelid of rats treated with epinephrine. This study provides further evidence epinephrine administration can result in chemical sympathectomy as has been described following 6-hydroxydopamine.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the Association for Research in Vision and Ophthalmology