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Investigative Ophthalmology & Visual Science, Vol 24, 976-980, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Localization of S-100 protein in Muller cells of the retina--1. Light microscopical immunocytochemistry

G Terenghi, D Cocchia, F Michetti, AR Diani, T Peterson, DF Cole, SR Bloom and JM Polak

S-100 is an acidic brain protein previously found to be present in glial cells of the brain and the nervous system of gut and respiratory tract. Immunocytochemistry at the light microscopical level localized immunoreactivity for S-100 in the Muller cells in the retina of rat, guinea pig, and Chinese hamster. The Muller cells represent the main glial component of the retina, with a structural role in the support and insulation of neurons and sensory elements. The use of S-100 protein as an immunocytochemical marker of Muller cells may be useful in the study of pathologic conditions of the retina where glial cell proliferation could reflect the index of neuronal injury.


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