IOVS Journal of Neurophysiology
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Investigative Ophthalmology & Visual Science, Vol 24, 980-984, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Localization of S-100 protein in Muller cells of the retina--2. Electron microscopical immunocytochemistry

D Cocchia, JM Polak, G Terenghi, F Battaglia, V Stolfi, C Gangitano and F Michetti

The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Muller cells, offering conclusive evidence that in the mammalian retina, the protein is confined to glial cells. S- 100, as a marker for Muller cells, may be a useful tool in order to study the cytoarchitecture of the retina in normal as well as in pathologic conditions. In addition, the retina may represent a suitable model for further investigation on the biologic role of S-100.




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Copyright © 1983 by the Association for Research in Vision and Ophthalmology