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Investigative Ophthalmology & Visual Science, Vol 24, 1070-1078, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Ocular lesions in mice following intracerebral injection of herpes simplex virus type I

RL Peiffer Jr, CD Dekker and FL Siegel

A clinical isolate of type I Herpes virus was injected intracerebrally in 4-week-old Balb/C mice. Bilateral ocular disease was observed initially clinically as a leukocoria and an anterior uveitis on the 7th to 11th postinjection days. By day 21 an organized vascularized retrolental membrane had formed with resolution of active inflammation and secondary cataract formation. Light microscopy revealed the process to involve a necrotizing retinitis with associated optic nerve demyelination. Electron microscopy and tissue culture demonstrated the virus in involved tissues.


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[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology