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Investigative Ophthalmology & Visual Science, Vol 24, 1098-1102, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Efficacy of antifungal agents in the cornea. I. A comparative study

DM O'Day, R Robinson and WS Head

A standardized model of Candida albicans keratitis was developed in pigmented rabbits using a quantitative mycologic technique to evaluate the disease at intervals throughout the course. In this model, using two different infecting strains, the efficacy of five antifungal agents was compared. Amphotericin B, in concentrations of 0.5% to 0.075%, was superior to all other agents tested. Natamycin 5% ranked next, followed by 1% flucytosine, and 1% miconazole. Ketoconazole 1% was ineffective.


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D. M. O’Day, W. S. Head, C. Csank, D. J. Shetlar, R. D. Robinson, G. W. McCollum, R. Yang, T. L. Zhu, and M. X. Wang
Differences in Virulence between Two Candida albicans Strains in Experimental Keratitis
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1116 - 1121.
[Abstract] [Full Text]


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology