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Investigative Ophthalmology & Visual Science, Vol 25, 1206-1209, Copyright © 1984 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effect of topically applied forskolin on aqueous humor dynamics in cynomolgus monkey

PY Lee, SM Podos, T Mittag and C Severin

Topical administration of a 1% forskolin suspension significantly reduced intraocular pressure in cynomolgus monkey eyes. The fall in intraocular pressure was associated with a significant (P less than 0.01) decrease in aqueous humor flow measured by a fluorophotometric technique. No significant change was found in tonographic outflow facility or pupillary diameter. A loss of effect on intraocular pressure to subsequent doses of 1% forskolin suspension occurred in cynomolgus monkeys by the third day of twice-a-day treatment.


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