IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Day, D. M.
Right arrow Articles by Robinson, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Day, D. M.
Right arrow Articles by Robinson, R. D.

Investigative Ophthalmology & Visual Science, Vol 25, 855-859, Copyright © 1984 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Influence of the corneal epithelium on the efficacy of topical antifungal agents

DM O'Day, WA Ray, WS Head and RD Robinson

A model of deep stromal Candida albicans infection was established by injecting 25 microliters of a suspension containing 5 X 10(9) colony forming units/ml of the yeast into corneas of pigmented rabbits. In this model, the infection lasts for more than 8 days. Using quantitative techniques, the authors compared the efficacy of six topical antifungal agents in the presence of an intact epithelium and in corneas debrided of epithelium. In corneas debrided on a daily basis, the polyenes (amphotericin B 0.15% and 0.075% and natamycin 5%) exhibited a significant antifungal effect. When the epithelium was left intact, 5% natamycin and 0.075% amphotericin B were without effect, while the efficacy of the 0.15% preparation of amphotericin B was much reduced. Removal of the epithelium appeared to affect adversely the efficacy of flucytosine. The imidazoles were not efficacious in this model.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
P. A. Thomas
Current Perspectives on Ophthalmic Mycoses
Clin. Microbiol. Rev., October 1, 2003; 16(4): 730 - 797.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
D. M. O’Day, W. S. Head, C. Csank, D. J. Shetlar, R. D. Robinson, G. W. McCollum, R. Yang, T. L. Zhu, and M. X. Wang
Differences in Virulence between Two Candida albicans Strains in Experimental Keratitis
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1116 - 1121.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by the Association for Research in Vision and Ophthalmology