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Investigative Ophthalmology & Visual Science, Vol 25, 860-863, Copyright © 1984 by Association for Research in Vision and Ophthalmology


ARTICLES AND REPORTS

Conjunctival epithelial wound healing

HS Geggel, J Friend and RA Thoft

In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithelium during reepithelialization. After 1 day of wounding, goblet cells disappeared several millimeters peripheral to the wound margin in both types of wounds. Goblet cells first reappeared peripherally 1 week after wounding before they appeared in the central wound area. These observations indicate that a large area of conjunctival epithelium surrounding a wound is involved with repair of that wound. Since the goblet cell content of conjunctival epithelium appears to change as a result of the stresses of epithelial repair, the goblet cell population may reflect the presence of reparative or proliferative processes in the ocular surface.


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W.-C. Hsu, M. H. Spilker, I. V. Yannas, and P. A. D. Rubin
Inhibition of Conjunctival Scarring and Contraction by a Porous Collagen-Glycosaminoglycan Implant
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2404 - 2411.
[Abstract] [Full Text]




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