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Investigative Ophthalmology & Visual Science, Vol 25, 1051-1055, Copyright © 1984 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effect of MPG on glucocorticoid-induced cataract formation in developing chick embryo

H Nishigori, R Hayashi, JW Lee and M Iwatsuru

Cataract in the developing chick embryo can be easily produced by administration of high doses of glucocorticoid and the cataract is preceded by a decreased level of glutathione in the lens (Nishigori et al, Exp Eye Res 36:617, 1983). In an attempt to prevent cataract formation, various natural and synthetic sulfhydryl compounds, glutathione, cysteine, ergothioneine, penicillamine, cysteamine and N- (2-mercaptopropionyl)glycine, were applied to hydrocortisone-treated developing chick embryos. N-(2-mercaptopropionyl)glycine showed the most potent delaying activity against cataract formation and also lessened the decrease of glutathione level in the lens. However, except for cysteamine, the other compounds tested had little or no effect.


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H. Watanabe, H. Kosano, and H. Nishigori
Steroid-Induced Short Term Diabetes in Chick Embryo: Reversible Effects of Insulin on Metabolic Changes and Cataract Formation
Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1846 - 1852.
[Abstract] [Full Text]


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