IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Young, E.
Right arrow Articles by Prendergast, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, E.
Right arrow Articles by Prendergast, R. A.

Investigative Ophthalmology & Visual Science, Vol 26, 116-121, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immunology of corneal allograft rejection: in vitro sensitization of effector cells

E Young, M Farazdaghi and RA Prendergast

Anterior chamber injection of donor rabbit lymphocytes sensitized in vitro to recipient alloantigens leads to the development of small focal areas of endothelial cell destruction (pocks) on the recipient cornea. Damage may be observed through a specular microscope as early as 2 days after injection of sensitized lymphocytes. Recipients of unsensitized allogeneic or sensitized autologous lymphocytes demonstrate little or no endothelial damage and no pock formation. Flat endothelial preparations reveal focal destruction of the endothelium with multiple foci, many infiltrated and surrounded by mononuclear cells. This model provides controlled sensitization to a variety of histocompatibility and corneal antigens that may be responsible for initiation of graft rejection.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the Association for Research in Vision and Ophthalmology