IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hara, S.
Right arrow Articles by Mizuno, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hara, S.
Right arrow Articles by Mizuno, K.

Investigative Ophthalmology & Visual Science, Vol 26, 1631-1634, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Phagocytosis of polystyrene spheres in the rabbit corneal endothelium: contribution of lysosomal enzymes to the endothelial degeneration

S Hara, S Ishiguro and K Mizuno

The rabbit corneal endothelium phagocytized polystyrene spheres 0.5 micron in diameter. After phagocytizing spheres, the endothelium degenerated, and lost from the Descemet's membrane. Lysosomal enzyme activities of the endothelium-Descemet's membrane complex, such as acid phosphatase, beta-glucuronidase and N-acetyl-beta-D-glucosaminidase, were assayed and the total activities per microgram DNA were almost constant. The unsedimentable activities in the complex, however, increased by phagocytosis of polystyrene spheres, which indicated an extralysosomal release of lysosomal enzymes. Released lysosomal enzymes probably would have accounted for the degeneration of the corneal endothelium.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the Association for Research in Vision and Ophthalmology