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Investigative Ophthalmology & Visual Science, Vol 26, 1634-1636, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Hydration stability of intracorneal hydrogel implants

WH Beekhuis and BE McCarey

A hydrogel intracorneal lens for refractive keratoplasty must have predictable and stable optics when implanted in the corneal stroma. A series of experiments was performed to evaluate the hydrogel hydration stability when in the corneal stromal environment. Hydrogel ICLs of 54%, 63%, 66% and 71% water content showed no loss of hydration (by weight) after one week in the rabbit corneal stroma. In vitro experiments with hydrogel discs of 56%, 65%, 69.5% and 75% water content were subjected to swelling pressures ranging from 55 to 150 mmHg in a suction chamber. Only the hydrogel of 75% water content showed a significant loss of hydration at the physiologic swelling pressure of 55 mmHg. This study shows that hydrogel materials with up to 69.5% water content can be expected to be dimensionally stable when used in keratorefractive surgery.


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 Journal of Bioactive and Compatible PolymersHome page
E.M. D'urso and G. Fortier
New Bioartificial Polymeric Material: Poly(ethylene glycol) Cross-Linked with Albumin. I. Synthesis and Swelling Properties
Journal of Bioactive and Compatible Polymers, January 1, 1994; 9(4): 367 - 387.
[Abstract] [PDF]


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Copyright © 1985 by the Association for Research in Vision and Ophthalmology