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Investigative Ophthalmology & Visual Science, Vol 26, 1784-1788, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of dexamethasone on the synthesis of collagen in normal human trabecular meshwork explants

MR Hernandez, BI Weinstein, MW Dunn, GG Gordon and AL Southren

This study demonstrates that the trabecular meshwork cells of the human eye incorporate 3H-Proline into collagen during in vitro incubation. Addition of dexamethasone to the incubation mixture produced a marked decrease in this incorporation. Dexamethasone was active at 10(-8) M and higher concentrations. The specificity of the hormone effect was demonstrated by its inability to alter 3H-leucine incorporation in these cells. These results indicate that dexamethasone decreases the synthesis of collagen, a major component of the extracellular matrix, in the trabecular meshwork.


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