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Investigative Ophthalmology & Visual Science, Vol 26, 243-246, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Molecular basis of an inherited retinal defect in Drosophila

F Wong, KM Hokanson and LT Chang

Fruitflies carrying the autosomal recessive mutation transient receptor potential (trp) are blind in bright light because the receptor potential of such a mutant decays almost completely during an intense stimulus. The trp gene has been localized and a set of partially overlapping genomic clones that include the trp gene has been isolated. The stretch of DNA represented by these genomic clones is found to contain genes that encode for four RNA species. Two of these RNA species are missing in the mutant. This observation is consistent with the notion that the mutation alters the DNA sequence in a region containing signals necessary for the expression of the gene. Accordingly, the molecular basis of the mutant phenotype may be due to the lack of a protein(s) that is/are important for normal visual transduction.


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C Montell, K Jones, E Hafen, and G Rubin
Rescue of the Drosophila phototransduction mutation trp by germline transformation
Science, November 29, 1985; 230(4729): 1040 - 1043.
[Abstract] [PDF]


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Copyright © 1985 by the Association for Research in Vision and Ophthalmology